Supplements

Betulin is a naturally occurring triterpene found in the outer bark of birch trees. It has been used for centuries in traditional medicine to treat various ailments such as inflammation, pain, and skin disorders. Recently, there has been a growing interest in the use of betulin as a dietary supplement due to its potential health benefits.

One of the main benefits of betulin is its anti-inflammatory properties. Studies have shown that betulin can inhibit the production of pro-inflammatory cytokines and chemokines in vitro, which may help reduce inflammation in the body (1). In addition, betulin has been shown to have analgesic properties, which may help relieve pain (2).

Another potential benefit of betulin is its ability to support healthy cholesterol levels. Animal studies have shown that betulin can lower total cholesterol and triglyceride levels in the blood (3). This may be due to its ability to inhibit the activity of enzymes involved in cholesterol synthesis.

Betulin also has antioxidant properties, which may help protect cells from damage caused by free radicals. In vitro studies have shown that betulin can scavenge free radicals and protect cells from oxidative stress (4).

There are various forms of betulin supplements available in the market, including betulinic acid, betulinic acid extract, and betulin enriched extracts. The dosage and form of betulin supplements can vary depending on the manufacturer.

More research is needed to fully understand Betulins’ mechanisms of action and its effects on human health. As with any dietary supplement, it's important to consult with a healthcare professional before taking betulin supplements.

References:

  1. Yamazaki T, Kaji T, Ishige K, et al. Betulinic acid, a natural pentacyclic triterpenoid, inhibits TNF-α-induced NF-κB activation through suppression of IKKβ phosphorylation in human keratinocytes. Acta Derm Venereol. 2014;94(6):701-6.

  2. Ma X, Pan R, Chen Y, et al. Betulin exhibits analgesic activity in animal models of acute pain and neuropathic pain. Pharmacol Biochem Behav. 2016;139(Pt A):57-64.

  3. Kim JY, Kwon EY, Jung UJ, et al. Betulin and its derivatives as potential agents for the prevention and treatment of obesity and metabolic diseases. Phytother Res. 2014;28(10):1493-500.

  4. Thiyagarajan V, Lin SH, Chia YC, Weng CF. Potential antioxidant betulin from fruits of Melaleuca bracteata. Food Chem Toxicol. 2012;50(3-4):979-85.